Tiletamine

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What is tiletamine used for?

It is used in veterinary medicine in the combination product Telazol (tiletamine/zolazepam, 50 mg/ml of each in 5 ml vial) as an injectable anesthetic for use in cats and dogs. It is sometimes used in combination with xylazine (Rompun) to chemically immobilize large mammals such as polar bears and wood bison.

Buy Tiletamine zolazepam online without prescription NMDA antagonist benzodiazepine tranquilizer 

Tiletamine zolazepam is an NMDA antagonist benzodiazepine tranquilizer combination of equal amounts with the dose based upon the combined weight of both drugs. Tiletamine is more potent and has a longer duration of action compared to ketamine. Tiletamine zolazepam is used as an alternative to ketamine combinations (ketamine+opioid, benzodiazepine, or alpha2-agonist) to produce immobilization, sedation, or surgical anesthesia for minor to moderate procedures. Buy Tiletamine Online Without Script

Depending upon the dose and species, tiletamine zolazepam may be associated with prolonged recoveries. Ocular, laryngeal, pharyngeal, and pedal reflexes remain intact. Side effects associated with tiletamine zolazepam include dose-dependent decrease in cardiac output and hypotension. Buy Tiletamine zolazepam online without prescription

In rabbits, tiletamine zolazepam has been associated with renal toxicity when used at surgical anesthetic doses (Brammer et al., 1991). Renal toxicity was linked to the tiletamine component. When used at lower doses in combination with xylazine, tiletamine zolazepam produced mean surgical anesthesia duration of 72 minutes versus 35 minutes for xylazine ketamine with no nephrotoxicity observed (Doerning et al., 1992). In guinea pigs, tiletamine zolazepam doses up to 50 mg/kg produced short-term immobilization, but inadequate surgical anesthesia (Radde et al., 1996). In hamsters, anesthesia but not analgesia was achieved at doses of 50–80 mg/kg (Silverman et al., 1983Tiletamine/Zolazepam

Tiletamine/zolazepam (Telazol™) has been used as an anesthetic for rats. A mixture of tiletamine and zolazepam, it is presented as a powder for reconstitution. Used alone, at doses of 20 to 40 mg/kg, Telazol™ produces 30 to 60 minutes of surgical anesthesia, but corneal, pedal and swallowing reflexes are retained, so the assessment of anesthetic depth is difficult. The addition of xylazine greatly improves the analgesia produced, but results in marked cardiovascular depression, and the addition of butorphanol also increases analgesia but at the cost of variable respiratory depression (Ward et al., 1974; Silverman et al., 1983; Wilson et al., 1993). Given the cost of Telazol™, its relatively short shelf life following reconstitution, and questionable analgesia there seems little reason to use it in preference to the ketamine mixtures described above.

Tiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist. It is related chemically to ketamine. Tiletamine hydrochloride exists as odorless white crystals. Wikipedia
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Telazol is a nonnarcotic, nonbarbiturate, injectable anesthetic agent for dogs and cats. Chemically, TELAZOL is a combination of equal parts by weight of base of tiletamine hydrochloride (2-[ethylamino]-2-[2-thienyl]-cyclohexanone hydrochloride), an arylaminocycloalkanone dissociative anesthetic, and zolazepam hydrochloride (4-[o-fluorophenyl]-6, 8-dihydro-1,3,8- trimethylpyrazolo [3, 4-e] [1,4] diazepin-7 [1H]-1- hydrochloride), a non-phenothiazine diazepinone having minor tranquilizing properties. The product is supplied sterile in vials. The addition of 5 mL diluent produces a solution containing the equivalent of 50 mg tiletamine base, 50 mg zolazepam base and 57.7 mg mannitol per milliliter. This solution has a pH of 2 to 3.5 and is recommended for deep intramuscular injection. Buy Tiletamine Online, Dog anesthesia, Cat anesthesia.

ACTIONS

Telazol is a rapid-acting anesthetic combination of tiletamine hydrochloride and zolazepam hydrochloride. Tiletamine hydrochloride is a dissociative anesthetic agent whose pharmacologic action is characterized by profound analgesia, normal pharyngeallaryngeal reflexes and cataleptoid anesthesia. The anesthetic state produced does not fit into the conventional classification of stages of anesthesia, but instead TELAZOL produces a state of unconsciousness which has been termed “dissociative’’ anesthesia in that it appears to selectively interrupt association pathways to the brain before producing somesthetic sensory blockade. Buy Tiletamine Online, Dog anesthesia, Cat anesthesia.

Cranial nerve and spinal reflexes remain active; however, these reflexes must not be confused with inadequate anesthesia. Analgesia results from apparent selective interruption of sensory inputs to the brain and usually persists after the anesthetic effect has subsided.

Protective reflexes, such as coughing and swallowing, are maintained under tiletamine anesthesia. Other reflexes, e.g., corneal, pedal, are maintained during tiletamine anesthesia, and should not be used as criteria for judging depth of anesthesia. The eyes normally remain open with the pupil dilated. It is suggested that a bland ophthalmic ointment be applied to the cornea if anesthesia is to be prolonged. Buy Tiletamine Online, Dog anesthesia, Cat anesthesia.

Used alone, tiletamine hydrochloride does not provide adequate muscle relaxation for abdominal surgical procedures. When combined with zolazepam hydrochloride, good muscle relaxation is generally attained during the phase of deep surgical anesthesia.

Following a single, deep intramuscular injection of TELAZOL in cats and dogs, onset of anesthetic effect usually occurs within 5 to 12 minutes. Muscle relaxation is optimum for approximately the first 20 to 25 minutes after TELAZOL is administered, and then diminishes. Buy Tiletamine Online, Dog anesthesia, Cat anesthesia.

Recovery varies with the age and physical condition of the animal and the dose of TELAZOL administered, but usually requires several hours. Recovery is extended with multiple injections, particularly in cats. Quality Telazol for Sale Online, Dog and Cat anesthesia .

Repeated doses increase the duration of the effect of TELAZOL but may not further diminish muscle tone. The quality of anesthesia with repeated doses varies because the ratio of the two components within the animal’s body changes with each injection. This is due to the difference in the rates of metabolism and elimination of the two components. The quality of anesthesia will be improved and more predictable if the entire dose is given as a single injection rather than in several doses. The best method of evaluating the depth of TELAZOL anesthesia is to monitor the patient for deliberate conscious response to nociceptive stimuli.

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