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Please make sure you read the enclosed leaflet carefully before taking Celebrex and celecoxib tablets. For adults, the recommended dose is as follows:
- Celebrex or celecoxib 100mg – take one capsule twice a day
- Celebrex or celecoxib 200mg – take one capsule daily
You should not exceed more than 200mg per day.
The risk of side effects associated with heart problems may increase with the dose and duration of use. It is, therefore, important that you use the lowest dose that controls your pain. You should not take Celebrex for longer than is necessary to control the symptoms. Celebrex should be swallowed whole with a drink of water. The capsules can be taken at any time of the day, with or without food. However, try to take each dose of Celebrex at the same time every day. Contact your doctor within two weeks of starting treatment if you do not feel any benefits.
Celebrex and celecoxib can be harmful to the stomach – especially if you are at a higher risk of stomach side effects– so we recommend that you also take another medicine to protect the stomach while you are taking this treatment. These can include Omeprazole 20mg Capsules or Zoton FasTab 30mg Tablets (lansoprazole) and should be taken once a day. People at a higher risk of stomach side effects include those who:
- Heavily smoke or drink
- Are aged 65 and over
- Are already taking ibuprofen at the maximum recommended dose Live with other medical conditions such as diabetes, heart disease, high blood pressure and liver or kidney complaints
- Have a history of stomach problems
Are Celebrex and celecoxib suitable for me?
You’ll find that in certain situations, Celebrex and celecoxib may be recommended for use with caution or even not recommended at all. Do not take Celebrex or celecoxib tablets:
- If you are allergic to celecoxib or any of the other ingredients of this medicine (listed in section six)
- If you have had an allergic reaction to a group of medicines called sulphonamides (for example, some antibiotics used to treat infections)
- If you have an ulcer in your stomach or intestines, or bleeding in your stomach or intestines
- If, as a result of taking acetylsalicylic acid (aspirin) or any other anti-inflammatory and pain-relieving medicine (NSAID), you have had asthma, nose polyps, severe nose congestion, or an allergic reaction such as an itchy skin rash, breathing difficulties and wheezing or swelling of the face, lips, tongue or throat
- If you are pregnant. It’s worth bearing in mind that if you become pregnant during ongoing treatment, you should talk to your doctor about methods of contraception
- If you are breastfeeding
- If you have been diagnosed with severe liver or kidney disease
- If you have ulcerative colitis, Crohn’s disease or any otherinflammatory disease of the intestines
- If you have heart failure, established ischaemic heart disease, or cerebrovascular disease, that is, if you have been diagnosed with a heart attack, stroke, or transient ischaemic attack (temporary reduction of blood flow to the brain, which is also known as “mini-stroke”), angina, or blockages of blood vessels to the heart or brain
- If you have or have had problems with your blood circulation (peripheral arterial disease) or if you have had surgery on the arteries in your leg
Check with your doctor or pharmacist before taking Celebrex or celecoxib tablets:
- If you have previously experienced an ulcer or bleeding in your stomach or intestines
- If you are taking aspirin (acetylsalicylic acid) – even at a low dose for heart protective purposes
- If you use medicines to reduce blood clotting (warfarin, for example)
- If you smoke, have diabetes, raised blood pressure or raised cholesterol
- If your heart, liver or kidneys are not working well. In this case, your doctor may want to keep a regular check on you
- If you have fluid retention (such as swollen ankles and feet)
- If you are dehydrated, for instance due to sickness, diarrhoea or the use of diuretics
- If you have had a serious allergic reaction or a serious skin reaction to any medicines
- If you feel ill due to an infection or suspect you may have an infection as Celebrex may mask a fever or other signs of infection and inflammation
Some cases of severe liver reactions, including severe liver inflammation, liver damage and liver failure (some with fatal outcome or requiring liver transplant), have been reported with celecoxib. Of the cases that reported time to onset, most severe liver reactions occurred within one month of the start of treatment.
Celebrex and celecoxib may make it more difficult to become pregnant so inform your doctor if you are planning to start a family or if you’re having problems getting pregnant.
You should be aware of how you react to Celebrex and celecoxib before you drive or operate machinery. If you feel dizzy or drowsy after taking Celebrex or celecoxib, do not do either until these effects wear off. During your consultation, it is important to inform us of any other medicines you’re taking, either prescribed by your doctor or bought from a pharmacy (non-prescription). Celebrex and celecoxib can cause problems if taken with certain other medicines, including:
- Non-acetylsalicylic NSAIDs such as ibuprofen or diclofenac
- Dextromethorphan (used to treat coughs)
- ACE inhibitors or angiotensin II antagonists (used for high blood pressure and heart failure)
- Diuretics (used to treat excess fluid in the body)
- Fluconazole and rifampicin (used to treat fungal and bacterial infections)
- Warfarin or other oral anticoagulants (“blood-thinning” agents that work to reduce clotting in the blood)
- Lithium (used to treat depression)
- Other medicines to treat depression, sleep disorders, high blood pressure or an irregular heartbeat
- Neuroleptics (used to treat some mental disorders)
- Methotrexate (used for treatment of rheumatoid arthritis, leukaemia and psoriasis)
- Carbamazepine (used to treat epilepsy/seizures and some forms of pain or depression)
- Barbiturates (used to treat epilepsy/seizures and some sleep disorders)
- Ciclosporin and tacrolimus (used for immune system suppression and, in many cases, after transplants)
You should always give a full picture of your general health in the consultation so that the doctor can be certain they have all the information required to assess your suitability to take Celebrex and celecoxib.
What are the side effects of Celebrex and celecoxib 100/200mg Tablets?
Celebrex and celecoxib are similar to all medicines in that they can cause side effects although not everybody will experience them. Side effects may include:
- Sinusitis, upper respiratory tract infection, urinary tract infection
- Insomnia, anxiety, depression, dizziness, headache, pins and needles, drowsiness
- Blurred vision, conjunctivitis, flu-like symptoms
- Tinnitus, hearing impairment
- Heart problems, raised blood pressure, palpitations, rapid heart rate
- Nausea, stomach pain, diarrhoea, constipation, indigestion, flatulence
- Skin itching or rash
- Joint pain, leg cramps
- Facial swelling or chest pain
For a comprehensive list of all potential side effects and other important information you need to be aware of, read the patient information leaflet provided before starting any course of treatment.
To talk to a UK registered GP about your condition, visit our Online Doctor service.